Health Adjusted GDP (HAGDP) Measures of the Relationship Between Economic Growth, Health Outcomes and Social Welfare

Welfare economic analysis of health issues and policies can provide well balanced orderings of the state of the economy. This paper provides an innovative framework for welfare economic analysis of the relationships between economic growth, health outcomes and social welfare for both a developing and a developed country. Economic growth can increase health outcomes and social welfare but its influence is limited by biological laws. Further, achieving economic growth may have negative externalities which reduce health outcomes (particularly when biological health limits are reached). A new health adjusted GDP indicator to investigate the relationship between economic growth, health outcomes and social welfare in both a developing and developed country using social choice perspectives is developed in this paper. This new approach to social welfare analysis is also based on cost-benefit analysis and systems analysis and is called the social choice approach. The importance of good health is crucial when determining social welfare. The major limitation of many health-based indicators is that they can fail to adequately consider social welfare issues, such as equity and efficiency. Social choice theory allows optimal health outcomes to be fully considered in terms of equity and efficiency when determining the impact of economic growth on social welfare. Social choice theory incorporates the various “social concerns” that are not adequately captured using individual preference satisfaction techniques. This paper analyses the health outcomes resulting from economic growth (costs and benefits) using Thailand and Australia as case studies, from 1975 to 1999. Two health adjusted gross domestic product (HAGDP) indices are prepared in this paper by adjusting GDP to reflect the social welfare impacts of achieving economic growth on health outcomes.

A note on bounds for the cop number using tree decompositions

In this short note, we supply a new upper bound on the cop number in terms of tree decompositions. Our results in some cases extend a previously derived bound on the cop number using treewidth

Merit - An evaluation tool for 100% renewable energy provision

Islands represent an interesting challenge in terms of energy supply. A great deal of work has been carried out to look at specific aspects of this issue on different islands. Unfortunately, results from one study cannot be easily applied to other islands due to island-specific resources and energy-use profiles. A quantitative evaluation tool (MERIT) is presented here, which is able to match half-hourly energy demands (heat, electricity, hot water and transport) with local supplies. The program examines the energy balance on any scale, from an individual building through to an entire country, thereby providing a powerful and generic aid to decision making. This paper demonstrates the generality and usefulness of MERIT by using it to analyse the options for creating an energy-autonomous community on a typical, small island off the west coast of Scotland. Results are presented showing the feasibility of accomplishing 100% renewable provision on this island using available local resources

The invertebrate Caenorhabditis elegans biosynthesizes ascorbate.

l-Ascorbate, commonly known as vitamin C, serves as an antioxidant and cofactor essential for many biological processes. Distinct ascorbate biosynthetic pathways have been established for animals and plants, but little is known about the presence or synthesis of this molecule in invertebrate species. We have investigated ascorbate metabolism in the nematode Caenorhabditis elegans, where this molecule would be expected to play roles in oxidative stress resistance and as cofactor in collagen and neurotransmitter synthesis. Using high-performance liquid chromatography and gas-chromatography mass spectrometry, we determined that ascorbate is present at low amounts in the egg stage, L1 larvae, and mixed animal populations, with the egg stage containing the highest concentrations. Incubating C. elegans with precursor molecules necessary for ascorbate synthesis in plants and animals did not significantly alter ascorbate levels. Furthermore, bioinformatic analyses did not support the presence in C. elegans of either the plant or the animal biosynthetic pathway. However, we observed the complete (13)C-labeling of ascorbate when C. elegans was grown with (13)C-labeled Escherichia coli as a food source. These results support the hypothesis that ascorbate biosynthesis in invertebrates may proceed by a novel pathway and lay the foundation for a broader understanding of its biological role

The role of built environment energy efficiency in a sustainable UK energy economy

Energy efficiency in the built environment can make significant contributions to a sustainable energy economy. In order to achieve this, greater public awareness of the importance of energy efficiency is required. In the short term, new efficient domestic appliances, building technologies, legislation quantifying building plant performance, and improved building regulations to include installed plant will be required. Continuing these improvements in the longer term is likely to see the adoption of small-scale renewable technologies embedded in the building fabric. Internet-based energy services will see low-cost building energy management and control delivered to the mass market in order that plant can be operated and maintained at optimum performance levels and energy savings quantified. There are many technology options for improved energy performance of the building fabric and energy systems and it's not yet clear which will prove to be the most economic. Therefore, flexibility is needed in legislation and energy-efficiency initiatives

The Awareness and Perception of Spyware amongst Home PC Computer Users

Spyware is a major threat to personal computer based data confidentiality, with criminal elements utilising it as a positive moneymaking device by theft of personal data from security unconscious home internet users. This paper examines the level of understanding and awareness of home computer users to Spyware. An anonymous survey was distributed via email invitation with 205 completed surveys. From an analysis of the survey it was found that the majority of respondents do understand what Spyware is, however, there was found to be a lack of understanding of computer security in defending against Spyware, with 20% of survey respondents not using any AntiSpyware. In addition, the subjective nature of survey respondent’s ideas of Spyware infected websites was established and compared to past webcrawl research where a high proportion of survey respondent’s opinions were found to be incorrect. It was also found respondents see Spyware as a ‘High/Some Threat’, and due to past infections and news/media articles 72% have changed their browsing habits

Clinical features of a novel TIMP-3 mutation causing Sorsby's fundus dystrophy: implications for disease mechanism

AIMS: To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3). METHODS: Three members of the same family were seen with a history of nyctalopia and visual loss due to maculopathy. Clinical features were consistent with Sorsby's fundus dystrophy. Exon 5 of the gene coding for TIMP-3 was amplified by the polymerase chain reaction, single strand conformation polymorphism analysis undertaken and exon 5 amplicons were directly sequenced. RESULTS: Onset of symptoms was in the third to fourth decade. Five of six eyes had geographic macular atrophy rather than neovascularisation as a cause for central visual loss. Peripheral retinal pigmentary disturbances were present. Scotopic ERGs were abnormal in all three. Mutation analysis showed a GT transversion in all three resulting in a premature termination codon, E139X, deleting most of the carboxy terminal domain of TIMP-3. CONCLUSIONS: The patients described had a form of Sorsby's fundus dystrophy which fell at the severe end of the spectrum of this disease. Postulated disease mechanisms include deposition of dimerised TIMP-3 protein

A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in sorsby's fundus dystrophy

Sorsby’s fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age. It has been shown to be caused by mutations in the gene for tissue inhibitor of metalloproteinases-3 (TIMP-3). Five different mutations have previously been identified, all introducing an extra cysteine residue into exon 5 (which forms part of the C-terminal domain) of the TIMP-3 molecule; however, the significance of these mutations to the disease phenotype was unknown. In this report, we describe the expression of several of these mutated genes, together with a previously unreported novel TIMP-3 mutation from a family with SFD that results in truncation of most of the C-terminal domain of the molecule. Despite these differences, all of these molecules are expressed and exhibit characteristics of the normal protein, including inhibition of metalloproteinases and binding to the extracellular matrix. However, unlike wild-type TIMP-3, they all form dimers. These observations, together with the recent finding that expression of TIMP-3 is increased, rather than decreased, in eyes from patients with SFD, provides compelling evidence that dimerized TIMP-3 plays an active role in the disease process by accumulating in the eye. Increased expression of TIMP-3 is also observed in other degenerative retinal diseases, including the more severe forms of agerelated macular degeneration, the most common cause of blindness in the elderly in developed countries. We hypothesize that overexpression of TIMP-3 may prove to be a critical step in the progression of a variety of degenerative retinopathies

Low Frequency VLA Observations of Abell 754: Evidence for a Cluster Radio Halo and Possible Radio Relics

We present 74 MHz and 330 MHz VLA observations of Abell 754. Diffuse, halo-like emission is detected from the center of the cluster at both frequencies. At 330 MHz the resolution of 90'' distinguishes this extended emission from previously known point sources. In addition to the halo and at a much lower level, outlying steep-spectrum emission regions straddle the cluster center and are seen only at 74 MHz. The location, morphology and spectrum of this emission are all highly suggestive of at least one, and possibly two cluster radio relics. Easily obtained higher resolution, higher sensitivity VLA observations at both frequencies are required to confirm the extended nature of the halo-like emission and the 74 MHz relic detections. However, since there is prior evidence that this cluster is or has recently been in the process of a major merger event, the possible discovery of relics in this system is of great interest in light of recent observational and theoretical evidence in favor of a merger-relic connection. We discuss the possible role the merger shock waves, which are seen in the X-ray emission, may have played in the formation of the halo and radio relics in A754.Comment: 15 pages including 4 figures. Accepted for publication by Ap